| Pair Name | Gambogic Acid, Docetaxel | ||
| Phytochemical Name | Gambogic Acid (PubChem CID: 9852185 ) | ||
| Anticancer drug Name | Docetaxel (PubChem CID: 148124 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gambogic Acid, Docetaxel | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| In Vitro Model | 3LL | Malignant tumors of the mouse pulmonary system | Mus musculus (Mouse) | CVCL_5653 |
| In Vivo Model | In an orthotopic mouse model of bone metastasis, the average survival of the DTX+GA combination group (32.61d±1.06 d) was significantly increased compared with that of the DTX group (25.75 d±0.67 d) or GA group (23.99 d±0.58 d), *P<0.01. | |||
| Result | The combination of DTX and GA has synergistic effect and resulted in more effective inhibition of tumor metastasis, providing a strong preclinical rationale for the clinical development of the DTX+GA combination for treating bone metastasis of lung cancer. | |||
| No. | Title | Href |
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| 1 | Synergistic effect of docetaxel and gambogic acid on bone metastasis of lung cancer. Bull Cancer. 2023 May;110(5):478-486. doi: 10.1016/j.bulcan.2023.02.007. | Click |
